Beilstein J. Org. Chem.2013,9, 2544–2555, doi:10.3762/bjoc.9.289
; natural products; ruthenium; Introduction
Bidirectionalsynthesis through termini differentiation of meso, C2-symmetric or unsymmetric building blocks has emerged as an important strategy in natural product synthesis over the past two decades [1]. Early on, enantiomerically pure C2-symmetric compounds
Beilstein J. Org. Chem.2010,6, 1206–1210, doi:10.3762/bjoc.6.138
diol. This development provides a basis for a stereocontrolled approach to the aminopolyol core of (−)-zwittermicin A using a bidirectionalsynthesis strategy.
Keywords: azide; bidirectionalsynthesis; cycloaddition; dialkoxydisiloxane; TIPDS; triazoline; triflic acid; zwittermicin A; Introduction
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Graphical Abstract
Scheme 1:
Retrosynthetic analysis outlining the stereocontrolled construction of the aminopolyol core of (−)-...